USC Keck School of Medicine, Department of Pathology is seeking a Postdoctoral Research Associate for NIH-funded research projects on cellular and molecular mechanisms of protective or pathogenetic actions mediated by Gasdermin-D and extracellular vesicles in the pathogenesis of hepatitis, liver fibrosis, and liver cancer.Â Genetic mouse models are used for liver disease models to define the causality and roles of cell-type specific Gasdermin-D in disease phenotypes.Â Biochemical and molecular analyses of specimens derived from such models will be carried out to define the mechanisms underlying phenotypes observed in the models. Two-three years of experience in the following areas are preferred.
Perform basic biochemical and molecular techniques (e.g., immunoblotting, co-immuno- precipitation, qPCR, ELISA, genotyping, plasmid preparation and cell culture and transfection)
Isolate and characterize extracellular vesicles from mouse plasma or conditioned media established by culture liver cells isolated from mouse disease models
Learn and perform analysis for RNAseq and scRNAseq data
Perform mouse breeding and experimentations
Organize data in Excel files, apply statistical analyses, and generate graphs and tables
Summarize experimental design, results, conclusions, and future plans using Power Point
Present research update to the Principal Investigator and laboratory members
Submit abstracts to national meetings for presentations of newly obtained findings
Write a draft of a manuscript and/or a progress report on the project
This is a grand-funded position-Fixed Term 12 months - renewable on the recommendation of the faculty mentor and the discretion of the dean.
Minimum Education:Ph.D. or equivalent doctorate within previous five yearsMinimum Experience:Directly related to biomedical research in the field of liver disease. Strong background in biochemistry, cell and molecular biology, and animal experimentation (mouse) is required.Preferred Education:Ph.D. in biochemistry, cell and molecular biology, physiology, or related fieldsPreferred Experience:Peer-reviewed publications in the same or related fields.Preferred Field of Expertise:Publications in peer-reviewed journals in the same or related field.Comments:A copy of the doctoral diploma or other certification that indicates that the terminal degree has been completed satisfactorily is required. If the doctoral candidate has not yet obtained a degree, he/she should provide evidence that a thesis has been approved together with a documented indication of the expected date of formal graduation. It is the responsibility of the faculty mentor to verify this documentation. The documentation is to be filed with the Postdoctoral Office.
USC is the leading private research university in Los Angeles—a global center for arts, technology and international business. With more than 47,500 students, we are located primarily in Los Angeles but also in various US and global satellite locations. As the largest private employer in Los Angeles, responsible for $8 billion annually in economic activity in the region, we offer the opportunity to work in a dynamic and diverse environment, in careers that span a broad spectrum of talents and skills across a variety of academic and professional schools and administrative units. As a USC employee and member of the Trojan Family—the faculty, staff, students, and alumni who make USC a great place to work—you will enjoy excellent benefits, including a variety of well-being programs designed to help individuals achieve work-life balance.