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Position overview Salary range: A reasonable estimate for this position is $66,737-$80,034. See Table Postdoctoral Scholar Experienced-Based Salary for the salary range for this position.
Application Window
Open date: July 23, 2025
Next review date: Friday, May 8, 2026 at 11:59pm (Pacific Time) Apply by this date to ensure full consideration by the committee.
Final date: Tuesday, Jun 30, 2026 at 11:59pm (Pacific Time) Applications will continue to be accepted until this date, but those received after the review date will only be considered if the position has not yet been filled.
Position description A postdoctoral position is available at the University of California, Irvine under the leadership of Dr. Stanley Ng. The successful candidate will explore the relationship between multiple molecular layers from epigenome to phenome at clonal resolution in various tissues. In brief, studies will involve the analysis of multiple data modalities from human and mouse tissues, including spatially-resolved somatic DNA mutations, gene and protein expression, cryogenic electron tomography (cryoET) images, among other data layers. Bioinformatic integration of distinct data types and subsequent statistical and machine learning analyses will be performed to elucidate how alterations to various molecular layers in individual clones can lead to their respective contributions to disease development/progression, malignant transformation, and treatment-specific resistance. For cryoET data, computer vision based deep learning models will be developed to identify abnormal biomolecular structures in diseased cells at nanoscale resolution. These studies will facilitate the identification of novel risk markers and therapeutic targets that will be validated in independent biological specimens and datasets.
Applicants should hold a PhD or MD/PhD degree and have extensive experience in at least 1 programming language and machine learning models. Ideally, candidates will also have some familiarity with basic biology, next-generation sequencing data, and statistical modelling of high-dimensional datasets, as reflected in published research articles. Postdocs are expected to work independently, while collaborating with bioinformaticians, biologists, clinicians, scientists, and otherwise obtain the necessary tools and knowledge as appropriate to achieve scientific aims.
Our lab employs bleeding-edge computational modelling approaches and state-of-the-art technologies. UC Irvine is a world-class research university with highly ranked graduate programs in biomedical sciences. Our Southern California location is home to one of the largest academic research and biotechnology hubs in the US. Lab members enjoy direct access to this outstanding community of clinicians and scientists, as well as the wide range of recreational activities available in our region. Successful candidates will join an interdisciplinary and highly collaborative team working to develop the next generation of tools and technologies to advance precision diagnostics and therapeutics.
Essential Skills
A PhD or MD/PhD degree with a focus on Epigenetics, Genetics, Genomics, Biology, Bioinformatics, Machine Learning, or a related field
Extensive experience in a research environment and at least 1 first-author publication in a reputable scientific journal
Proficiency in R, Python, and/or other programming languages, and familiarity with working in a Linux-based high-performance computing environment
Ability to work independently to drive projects forward
Ability to communicate effectively and collaborate as part of a multidisciplinary team
Ability to compose and deliver comprehensive presentations at scientific meetings and prepare research articles for peer-reviewed publications
Ideal Skills
Expertise in statistical model development and the analysis of high-dimensional data, including next generation sequencing datasets
Experience with sectioning, fixing, and staining tissues for histology imaging, laser capture microdissection, and sample prep for (single-cell) sequencing
Expertise with ATAC-Seq, methylation profiling, genome/exome/targeted sequencing, mutation calling, single-cell analysis, RNA-Seq, proteomics, spatial technologies from 10X, NanoString or similar, cryoET or cryoEM analysis.
Expertise in machine learning and mathematical/statistical inference (e.g., image classification/segmentation using deep neural networks, reinforcement learning, regularized regression and classification models, clustering, optimization)
Experience in developing computational analysis pipelines
Expertise with multi-core/multi-threaded parallelization using GPU-based hardware acceleration or similar
Experience with building highly distributable software (e.g., R packages, Python modules, Linux-based command-line tools, C programs, MATLAB applications, GitHub)
A doctoral degree (e.g., Ph.D., M.D.) or the foreign equivalent is required. The applicant can either have their PhD at the time of the application, or could be working towards the PhD.
Lab: https://ngbiomedresearch.softr.app/ Qualifications Basic qualifications (required at time of application) A doctoral degree (e.g., Ph.D., M.D.) or the foreign equivalent is required. The applicant can either have their PhD at the time of the application, or could be working towards the PhD. Application Requirements Document requirements
Cover Letter
Curriculum Vitae - Your most recently updated C.V.
Statement of Research - Describe prior experience, future goals, and research interests
About UC Irvine The University of California, Irvine is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age, protected veteran status, or other protected categories covered by the UC anti-discrimination policy.
As a condition of employment, the finalist will be required to disclose if they are subject to any final administrative or judicial decisions within the last seven years determining that they committed any misconduct.
'Misconduct' means any violation of the policies or laws governing conduct at the applicant's previous place of employment, including, but not limited to, violations of policies or laws prohibiting sexual harassment, sexual assault, or other forms of harassment or discrimination, as defined by the employer.
As a University employee, you will be required to comply with all applicable University policies and/or collective bargaining agreements, as may be amended from time to time. Federal, state, or local government directives may impose additional requirements. Job location Irvine, CA
Since 1965, the University of California, Irvine has combined the strengths of a major research university with the bounty of an incomparable Southern California location. UCI's unyielding commitment to rigorous academics, cutting-edge research, and leadership and character development makes the campus a driving force for innovation and discovery that serves our local, national and global communities.
