This Postdoctoral Scientist role is designed as a training opportunity for those who have recently completed their PhD or doctoral degree. To ensure we provide the intended mentorship and career development, we are looking for candidates who are within five years of completing their doctorate. If you're within this timeframe and excited about advancing your research in a supportive and collaborative environment, we encourage you to apply!
The Hosoya Lab investigates the dynamics interactions between engineered cell therapies, endogenous immune responses, and tumor evolution in hematologic malignancies. Our goal is to understand why cellular immunotherapies succeed, fail, or lead to late toxicities - and to use these insights to develop safer and more durable treatment strategies.
We integrate translational patient samples with advanced immune profiling approaches, including single-cell genomics, TCR repertoire analysis, spatial technologies, and functional immune assays. A major focus of the lab is to define mechanisms of late toxicities following CAR T-cell and other cellular immunotherapies, including prolonged cytopenias and immune dysregulation, and to uncover how host immunity shapes both therapeutic response and resistance. Through close collaboration between laboratory and clinical teams, our work bridges mechanistic immunology with real-world patient outcomes.
This postdoctoral position offers an opportunity to study the interplay between cellular immunotherapy, host immune ecosystems, and tumor biology in patients with hematologic cancers. The candidate will lead and contribute to a range of innovative projects focusing on mechanisms of response and resistance to CAR T-cell therapy, immune drivers of late toxicities, and clonal and immune evolution following treatment. The postdoc will work at the interface of laboratory research and clinical investigation within a highly collaborative and interdisciplinary environment.
Working independently but in close collaboration with the Principal Investigator and research team, the Postdoctoral Scientist will:
Design, execute, and interpret mechanistic immunology experiments
Perform and analyze single-cell, immune repertoire, and functional immune assays
Develop and implement new laboratory protocols
Analyze complex genomic and immunologic datasets
Maintain detailed experimental records and documentation
Operate and maintain equipments and instruments
Contribute to manuscript preparation and scientific presentation
Assist in grant writing and development of new research directions
Engage in translational collaboration with clinical investigators
This position provides mentorship in experimental design, scientific writing, grant development, and career advancement.
Qualifications
Requirements:
Doctorate (MD, PhD, VMD, or DDS) in area directly related to field of research specialization.
1 year, acquires thorough technical and theoretical knowledge of research project and objectives during one to five (1-5) year post-doctoral appointment.
This Postdoctoral Scientist role is designed as a training opportunity for those who have recently completed their PhD or doctoral degree. To ensure we provide the intended mentorship and career development, we are looking for candidates who are within 5years of completing their doctorate. If you're within this timeframe and excited about advancing your research in a supportive and collaborative environment, we encourage you to apply!
Preferred Skills:
Ph.D. in Immunology, Cancer Biology, Hematology, Genomics, or a related field
Experience working with human samples and familiarity with biospecimen processing and biobanking
Strong background in immunology, tumor immunology, or cellular immunology
Providing healthcare for more than 100 years, Cedars-Sinai has evolved into one of the most dynamic and highly renowned medical centers in the world. Along with caring for patients, Cedars-Sinai is a hub for biomedical research and a training center for future physicians and other healthcare professionals. This attracts exceptional talent to Cedars-Sinai, including world-renowned physician-scientists who seek a place where they can both conduct research and see patients--the ideal formula for discovery and its translation into cures. Our patients benefit from access to doctors at the top of their fields, and our researchers have an ideal community in which to study the impact of healthcare challenges, and reflect that knowledge in their research. The greater Los Angeles area in which Cedars-Sinai resides possesses unparalleled cultural and ethnic diversity which offers outstanding opportunities for translational and clinical research and a dynamic environment for medical education.Although community based, Cedars-Sinai is a major teaching hospital affiliated with the David Geffen School of Medicine at the University of California, Los Angeles (UCLA). Cedars-Sinai has highly competi...tive graduate medical education programs in more than 50 specialty and subspecialty areas, a graduate program in biomedical sciences and translational medicine, a clinical scholars program directed towards junior physicians with aspirations to become clinical scientists, and post graduate training opportunities.There are more than 250 full-time faculty members at Cedars-Sinai. The voluntary medical staff, comprised of more than 2,200 specialty board-certified or board-qualified physicians, represent all of the specialties and subspecialties and collaborate with full-time medical staff in the teaching responsibilities of the graduate medical education programs.
